• Welcome to the Gao lab!
    Our research lies at the interface of chemical biology and biomolecular engineering with a primary focus on small- and macro-molecule discovery and their applications to human health, agriculture, and energy.

    Selected publications:

    • Hu J.H., Miller S.M., Geurts M.H., Tang W., Chen L., Sun N., Zeina C.M., Gao, X., Rees H.A., Lin Z., Liu D.R., “Evolved Cas9 variants with broad PAM compatibility and high DNA specificity.” Nature2018, doi: 10.1038/nature26155.
    • Gao, X., Tao Y., Lamas, V., Chen, Z. Y., Liu, D. R., et al, “Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents.” Nature, 2018553, 217-221, doi:10.1038/nature25164.

    • Jiménez-Osés, G., Osuna S., Gao, X., Tang, Y., Houk, K. N. et al, “The Role of Distant Mutations and Allosteric Regulation on LovD Active Site Dynamics.” Nat. Chem. Biol.2014, (6):431-6.
    • Gao, X., Jiang, W, Houk K.N., Yi Tang, Walsh C.T. et al, “An Iterative, Bimodular Nonribosomal Peptide Synthetase that Converts Anthranilate and Tryptophan into Tetracyclic Asperlicins.” Chem. Biol.2013, 20, 870-878.
    • Gao, X., Haynes, S. W., Ames, B. D., Walsh, C. T., Tang, Y et al. “Cyclization of fungal nonribosomal peptides by a terminal condensation-Like domain.” Nat. Chem. Biol.2012, 8, 823-830.
    • Gao, X., Chooi, Y., Ames, B. D., Walsh, C. T., Tang, Y et al. “Fungal quinazoline alkaloid biosynthesis: Genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicum.” J. Am. Chem. Soc., 2011, 133, 2729-2741. (Highlighted by Nat. Chem. Biol.)
    • Gao, X., Wang, P., Tang, Y. “Engineered polyketides biosynthesis and biocatalysis in Escherichia coli.” Appl. Microbiol. Biotechnol., 2010, 88, 1233-1242.
    • Gao, X., Xie, X., Pashkov, I., Sawaya, R. M., Tang, Y et al. “Directed evolution and structural characterization of a simvastatin synthase.” Chem. Biol., 2009, 16, 1064-1074. (2012 Presidential Green Chemistry Challenge Award)
    • Gao, X., Xie, X., Tang, Y. “LovD mutants exhibiting improved properties towards simvastatin synthesis.” U.S. Patent No. 8,981,056 (Licensed Patent)


Mar. 1st, 2020 – We were super glad to have three fantastic speakers, Dr. Hal Alper, Dr. Yi Cui, and Dr. Fuzhong Zhang visit us in Feb 2020! Look forward to the rest of 2020!

Dec. 23rd, 2019 – Gao Group Hotpot Outing! Merry Christmas and Happy New Year!

Oct. 21-22, 2019- Sin, Ning, Qichen, Jie, and Sherry attended the Welch Conference! Sin and Qichen had great discussions with the Pioneers! Go Genome editing!

Sep. 30th, 2019- Shuqi has finished his visiting in our Group. We had a great farewell at Meet Fresh @ Houston!

Sep. 1st, 2019, 2019- Our group welcomes Dr. Zhiwen Liu (Postdoc), Dr. Jie Yang (Research Scientist), Qichen Yuan (Graduate Student) and Shuyuan Yang (Graduate Student)!

Aug. 29th, 2019- Our collaborative grant on CRISPR Delivery (Led by Prof. Gang Bao) was funded by NIH! Congrats!

Aug. 28th, 2019- A completely new start of the Gao Group!

Mar. 26th, 2019- Prof. Wenjun Zhang visited us and gave a fantastic seminar!

Jan. 31st, 2019- Prof. Chaitan Khosla visited us and gave the Wilber Lecture for Chemical and Biomolecular Engineers!

Jan. 6th-9th, 2019- Sherry attended the ICBE conference at NewPort Beach, California. Very inspired by all the great talks and communications! Particularly by the Nobel laureate Frances Arnold!

News archive.