• WE ARE HIRING for multiple positions! Our lab is actively looking for highly motivated postdoc researchers (2-year minimal), research assistants (2-year minimal), and graduate students who are interested in applying CRISPR technology for disease treatment and diagnosis, synthetic biology, metabolic engineering, and more! If you are interested, please do not hesitate to contact us at xue.gao@rice.edu!

    Welcome to the Gao lab! Our research lies at the interface of chemical biology and biomolecular engineering with a primary focus on small- and macro-molecule discovery and their applications to human health, agriculture, and energy.

    Selected publications:

    • Liu, W.W., An, C.Y., Shu, X., Meng, X.X., Yao, Y.P., Zhang, J., Chen, F.S., Xiang, H., Yang, S.Y., Gao, X.*, and Gao, S.S.*, “A dual-plasmid CRISPR/Cas system for mycotoxin elimination in polykaryotic industrial fungi.” ACS Synth. Biol., 2020, https://doi.org/10.1021/acssynbio.0c00178.
    • Ding, N., Lee, S.S., Lieber-Kotz, M.#, Yang, J., Gao, X.*, “Advances in Genome Editing for Genetic Hearing Loss.” Adv. Drug Deliv. Rev., 2020, doi.org/10.1016/j.addr.2020.05.001.
    • Hu J.H., Miller S.M., Geurts M.H., Tang W., Chen L., Sun N., Zeina C.M., Gao, X., Rees H.A., Lin Z., Liu D.R., “Evolved Cas9 variants with broad PAM compatibility and high DNA specificity.” Nature2018, doi: 10.1038/nature26155.
    • Gao, X., Tao Y., Lamas, V., Chen, Z. Y., Liu, D. R., et al, “Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents.” Nature, 2018553, 217-221, doi:10.1038/nature25164.

    • Jiménez-Osés, G., Osuna S., Gao, X., Tang, Y., Houk, K. N. et al, “The Role of Distant Mutations and Allosteric Regulation on LovD Active Site Dynamics.” Nat. Chem. Biol.2014, (6):431-6.
    • Gao, X., Jiang, W, Houk K.N., Yi Tang, Walsh C.T. et al, “An Iterative, Bimodular Nonribosomal Peptide Synthetase that Converts Anthranilate and Tryptophan into Tetracyclic Asperlicins.” Chem. Biol.2013, 20, 870-878.
    • Gao, X., Haynes, S. W., Ames, B. D., Walsh, C. T., Tang, Y et al. “Cyclization of fungal nonribosomal peptides by a terminal condensation-Like domain.” Nat. Chem. Biol.2012, 8, 823-830.
    • Gao, X., Chooi, Y., Ames, B. D., Walsh, C. T., Tang, Y et al. “Fungal quinazoline alkaloid biosynthesis: Genetic and biochemical investigation of the tryptoquialanine pathway in Penicillium aethiopicum.” J. Am. Chem. Soc., 2011, 133, 2729-2741. (Highlighted by Nat. Chem. Biol.)
    • Gao, X., Wang, P., Tang, Y. “Engineered polyketides biosynthesis and biocatalysis in Escherichia coli.” Appl. Microbiol. Biotechnol., 2010, 88, 1233-1242.
    • Gao, X., Xie, X., Pashkov, I., Sawaya, R. M., Tang, Y et al. “Directed evolution and structural characterization of a simvastatin synthase.” Chem. Biol., 2009, 16, 1064-1074. (2012 Presidential Green Chemistry Challenge Award)
    • Gao, X., Xie, X., Tang, Y. “LovD mutants exhibiting improved properties towards simvastatin synthesis.” U.S. Patent No. 8,981,056 (Licensed Patent)


July 7th, 2020 – Fanglong’s paper was just accepted by Angewandte Chemie! Great job Fanglong, Zhiwen and Shuyuan! Hard work pays off!

June 12th, 2020 – Check our new publication on using CRISPR technology for large gene fragment deletion in polykaryotic fungi! Just appeared online on ACS Synthetic Biology!

May 18th, 2020 – The First Gao Lab Research article is to be published in Science Advances! Thanks for all the co-authors! More coming!

May 8th, 2020 – Check 0ur comprehensive review of genome editing for genetic hearing diseases in Advanced Drug Delivery Reviews! Thanks for all the co-authors! Special Thanks to the Undergraduate coauthor Matan!

Mar. 1st, 2020 – We were super glad to have three fantastic speakers, Dr. Hal Alper, Dr. Yi Cui, and Dr. Fuzhong Zhang visit us in Feb 2020! I look forward to the rest of the 2020!

Dec. 23rd, 2019 – Gao Group Hotpot Outing! Merry Christmas and Happy New Year!

Oct. 21-22, 2019- The 2019 Welch Conference!  Go Genome editing!

Sep. 30th, 2019- Shuqi has finished his visiting in our Group. We had a great farewell at Meet Fresh @ Houston!

Sep. 1st, 2019, 2019- Our group welcomes Dr. Zhiwen Liu (Postdoc), Dr. Jie Yang (Research Scientist), Qichen Yuan (Graduate Student), and Shuyuan Yang (Graduate Student)!

Aug. 29th, 2019- Our collaborative grant on CRISPR Delivery (Led by Prof. Gang Bao) was funded by NIH! Congrats!

Aug. 28th, 2019- A completely new start of the Gao Group!

Mar. 26th, 2019- Prof. Wenjun Zhang visited us and gave a fantastic seminar!

Jan. 31st, 2019- Prof. Chaitan Khosla visited us and gave the Wilber Lecture for Chemical and Biomolecular Engineers!

Jan. 6th-9th, 2019- Sherry attended the ICBE conference at NewPort Beach, California. Very inspired by all the great talks and communications! Particularly by the Nobel laureate Frances Arnold!

News archive.