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  • Welcome to the Gao lab! Our research lies at the interface of chemical biology and biomolecular engineering with a primary focus on small- and macro-molecule discovery and their applications to human health, agriculture, and energy.

    Research Sponsored by:

    Selected publications:

    • Lee, S.S.†, Ding, N.†, Sun, Y.D, Yuan, T.L., Li, J., Yuan, Q.C., Liu, L.Z., Yang, J., Wang, Q., Kolomeisky, A.B., Hilton, I.B, Zuo, E.W.*, Gao, X.*,“Single C-to-T substitution using engineered APOBEC3G-nCas9 base editors with minimum genome- and transcriptome-wide off-target effects.” Sci. Adv., 2020, 10.1126/sciadv.aba1773.
    • Zhao, F.L., Liu, Z.W., Yang, S.Y., Ning, D., Gao, X.Quinolactacin Biosynthesis Involves NRPSs Catalyzed Dieckmann Condensation to Form the Quinolone‐γ‐lactam Hybrid.” Angew. Chem. Int. Ed. , 2020, doi.org/10.1002/anie.202005770.
    • Liu, W.W., An, C.Y., Shu, X., Meng, X.X., Yao, Y.P., Zhang, J., Chen, F.S., Xiang, H., Yang, S.Y., Gao, X.*, and Gao, S.S.*, “A dual-plasmid CRISPR/Cas system for mycotoxin elimination in polykaryotic industrial fungi.” ACS Synth. Biol., 2020, doi.org/10.1021/acssynbio.0c00178.
    • Ding, N., Lee, S.S., Lieber-Kotz, M.#, Yang, J., Gao, X.*, “Advances in Genome Editing for Genetic Hearing Loss.” Adv. Drug Deliv. Rev., 2020, doi.org/10.1016/j.addr.2020.05.001.
    • Gao, X., Tao Y., Lamas, V., Chen, Z. Y., Liu, D. R., et al, “Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents.” Nature, 2018553, 217-221, doi:10.1038/nature25164.

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NEWS

We Are Hiring!

Oct. 1st, 2020 – New research scientist Dacheng Ma joined the Gao lab! Welcome! Excited to set sail to new research projects!

Aug 31, 2020- Our collaborative proposal with Dr. Yi Zhang was just awarded to develop ultra-sensitive detection methods for food pathogens! Thanks, @NSF!

July 24, 2020- The Gao Lab received the Maximizing Investigators’ Research Award (MIRA) from NIGMS to support our research for the Next Five Years! Great News!

July 15, 2020- Check our new paper just published on Science Advances! Precise genome editing tools hold great promise for treating human genetic diseases!

July 14, 2020- Fanglong’s paper now is online in Angewandte Chemie! The first Gao lab research article. Check it out! 

July 14th, 2020 – New research scientist Jingbo Ma joined the Gao lab! Welcome!

July 7th, 2020 – Fanglong’s paper was just accepted by Angewandte Chemie! Great job Fanglong,  and Zhiwen! Hard work pays off!

June 12th, 2020 – Check our new publication on using CRISPR technology for large gene fragment deletion in polykaryotic fungi! Just appeared online on ACS Synthetic Biology!

May 8th, 2020 – Check 0ur comprehensive review of genome editing for genetic hearing diseases in Advanced Drug Delivery Reviews! Thanks for all the co-authors! Special Thanks to the Undergraduate coauthor Matan!

Mar. 1st, 2020 – We were super glad to have three fantastic speakers, Dr. Hal Alper, Dr. Yi Cui, and Dr. Fuzhong Zhang visit us in Feb 2020! I look forward to the rest of the 2020!

News archive.